ROI_001_BlueSMA_RedPan-CK_YellowCD8a_LimeCD45RO_Gauss_blur_3.tif

Publications

Selected publications

Diana Schaufler", David Ast", Hannah Tumbrink, Nima Abedpour, Lukas Maas, Ayla Schwäbe, Inga Spille, Stefanie Lennartz, Jana Fassunke, Mihaela Aldea, Benjamin Besse, David Planchard, Lucia Nogova, Sebastian Michels, Carsten Kobe, Thorsten Persigehl, Theresa Westphal, Sophia Koleczko, Rieke Fischer,Jan-Philipp Weber, Janine Altmüller, Roman K. Thomas, Sabine Merkelbach-Bruse, Oliver Gautschi, Laura Mezquita, Reinhard Büttner, Jürgen Wolf, Martin Peifer, Johannes Brägelmann*, Matthias Scheffler*, Martin Sos*.

Clonal dynamics of BRAF-driven drug resistance in EGFR-mutant lung cancer.

npj Precision Oncology

(*co-corresponding authors, "contributed equally)

Johannes Brägelmann*", Carina Lorenz", Sven Borchmann, Kazuya Nishii, Julia Wegner, Lydia Meder, Jenny Ostendorp, David Ast, Alena Heimsoeth, Takamasa Nakasuka, Atsuko Hirabae, Sachi Okawa, Marcel Dammert, Dennis Plenker, Sebastian Klein, Philipp Lohneis, Jianing Gu, Laura Godfrey, Jan Forster, Marija Trajkovic-Arsic, Thomas Zillinger, Mareike Haarmann, Alexander Quaas, Stefanie Lennartz, Marcel Schmiel, Joshua D’Rozario,Emily Thomas, Henry Li, Clemens A. Schmitt, Julie George, Roman K. Thomas, Silvia von Karstedt, Gunther Hartmann, Reinhard Büttner, Roland T. Ullrich, Jens T. Siveke, Kadoaki Ohashi, Martin Schlee, Martin Sos*

MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I.

Nature Communications

(*co-corresponding authors, "contributed equally)

Johannes Brägelmann, Carol Barahona Ponce, Katherine Marcelain, Stephanie Roessler, Benjamin Goeppert, Ivan Gallegos, Alicia Colombo, Verónica Sanhueza, Erik Morales, María Teresa Rivera, Gonzalo de Toro, Alejandro Ortega, Bettina Müller, Fernando Gabler, Dominique Scherer, Melanie Waldenberger, Eva Reischl, Felix Boekstegers, Valentina Garate-Calderon, Sinan U. Umu, Trine B. Rounge, Odilia Popanda, Justo Lorenzo Bermejo

Epigenome‐wide analysis of methylation changes in the sequence of gallstone disease, dysplasia, and gallbladder cancer.

Hepatology 2020

Christian Watermann, Helen Pasternack, Christian Idel, Julika Ribbat-Idel, Johannes Brägelmann, Patrick Kuppler, Anne Offermann, Danny Jonigk, Mark Philipp Kühnel, Andreas Schröck, Eva Dreyer, Christian Rosero, Jacqueline Nathansen, Anna Dubrovska, Lars Tharun, Jutta Kirfel, Barbara Wollenberg, Sven Perner, Rosemarie Krupar

Comparative immune microenvironment analyses of primary and recurrent HNSCC reveal immunosuppression in recurrences suggesting successful tumor immune evasion.

Clinical Cancer Research 2021

2021

Finn-Ole Paulsen, Christian Idel, Julika Ribbat-Idel, Patrick Kuppler, Luise Klapper, Dirk Rades, Karl-Ludwig Bruchhage, Barbara Wollenberg, Johannes Brägelmann, Sven Perner, Anne Offermann

CDK19 as a Potential HPV-Independent Biomarker for Recurrent Disease in HNSCC

IJMS 2020

Finn Becker, Vincent Joerg, Marie C. Hupe, Doris Roth, Rosemarie Krupar, Verena Lubczyk, Rainer Kuefer, Verena Sailer, Stefan Duensing, Jutta Kirfel, Axel S. Merseburger, Johannes Brägelmann, Sven Perner, Anne Offermann

Increased mediator complex subunit CDK19 expression associates with aggressive prostate cancer

International Journal of Cancer 2020

2020

Marcel A. Dammert*, Johannes Brägelmann*, Rachelle R. Olsen, Stefanie Böhm, Niloufar Monhasery, Christopher P. Whitney, Milind D. Chalishazar, Hannah L. Tumbrink, Matthew R. Guthrie, Sebastian Klein, Abbie S. Ireland, Jeremy Ryan, Anna Schmitt, Annika Marx, Luka Ozretić, Roberta Castiglione, Carina Lorenz, Ron D. Jachimowicz, Elmar Wolf, Roman K. Thomas, John T. Poirier, Reinhard Büttner, Triparna Sen, Lauren A. Byers, H. Christian Reinhardt, Anthony Letai, Trudy G. Oliver & Martin L. Sos

MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer

Nature Communications 2020

(*contributed equally)

Matthias Scheffler, Michaela A Ihle, Rebecca Hein, Sabine Merkelbach-Bruse, Andreas H Scheel, Janna Siemanowski, Johannes Brägelmann, Anna Kron, Nima Abedpour, Frank Ueckeroth, Merle Schüller, Sophia Koleczko, Sebastian Michels, Jana Fassunke, Helen Pasternack, Carina Heydt, Monika Serke, Rieke Fischer, Wolfgang Schulte, Ulrich Gerigk, Lucia Nogova, Yon-Dschun Ko, Diana S Y Abdulla, Richard Riedel, Karl-Otto Kambartel, Joachim Lorenz, Imke Sauerland, Winfried Randerath, Britta Kaminsky, Lars Hagmeyer, Christian Grohé, Anna Eisert, Rieke Frank, Leonie Gogl, Carsten Schaepers, Alessandra Holzem, Martin Hellmich, Roman K Thomas, Martin Peifer, Martin L Sos, Reinhard Büttner, Jürgen Wolf

K-ras Mutation Subtypes in NSCLC and Associated Co-occuring Mutations in Other Oncogenic Pathways

Journal of Thoracic Oncology 2019

Sebastian Michels, Carina Heydt, Bianca van Veggel, Barbara Deschler-Baier, Nuria Pardo, Kim Monkhorst, Vanessa Rüsseler, Jan Stratmann, Frank Griesinger, Susanne Steinhauser, Anna Kostenko, Joachim Diebold, Jana Fassunke, Rieke Fischer, Walburga Engel-Riedel, Oliver Gautschi, Eva Geissinger, Stefan Haneder, Michaela A Ihle, Hans-Georg Kopp, Adrianus J de Langen, Alex Martinez-Marti, Lucia Nogova, Thorsten Persigehl, Dennis Plenker, Michael Puesken, Ernst Rodermann, Andreas Rosenwald, Andreas H Scheel, Matthias Scheffler, Werner Spengler, Ruth Seggewiss-Bernhardt, Johannes Brägelmann, Martin Sebastian, Bart Vrugt Martin Hellmich, Martin L Sos, Lukas C Heukamp, Enriqueta Felip, Sabine Merkelbach-Bruse, Egbert F Smit, Reinhard Büttner, Jürgen Wolf

Genomic Profiling Identifies Outcome-Relevant Mechanisms of Innate and Acquired Resistance to Third-Generation Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy in Lung Cancer

JCO Precision Oncology 2019

2019

2018

Johannes Brägelmann, Marcel A. Dammert, Felix Dietlein, Johannes M. Heuckmann, Axel Choidas, StefanieBöhm, André Richters, Debjit Basu, Verena Tischler, Carina Lorenz, Peter Habenberger, Zhizhou Fang, Sandra Ortiz-Cuaran, Frauke Leenders, Jan Eickhoff, Uwe Koch, Matthäus Getlik, Martin Termathe, Muhammad Sallouh, Zoltán Greff, Zoltán Varga, Hyatt Balke-Want, Christopher A. French, Martin Peifer, H. Christian Reinhardt, László Örfi, György Kéri, Sascha Ansén, Lukas C.Heukamp, Reinhard Büttner, Daniel Rauh, Bert M. Klebl, Roman K. Thomas, Martin L. Sos

Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline Carcinoma

Cell Reports 2017

Gurkan Mollaoglu*, Matthew Guthrie*, Stefanie Böhm*, Johannes Brägelmann*, Ismail Can, Paul M. Ballieu, Annika Marx, Julie George, Christine Heinen, Milind D. Chalishazar, Haixia Cheng, Abbie S. Ireland, Kendall E. Denning, Anandaroop Mukhopadhyay, Jeffery M. Vahrenkamp, Kristofer C. Berrett, Timothy L. Mosbruger, Jun Wang, Jessica L. Kohan, Mohamed E. Salama, Benjamin L. Witt, Martin Peifer, Roman K. Thomas, Jason Gertz, Jane E. Johnson  Adi F. Gazdar, Robert J. Wechsler-Reya, Martin L. Sos, Trudy G. Oliver

MYC Drives Progression of Small Cell Lung Cancer to a Variant Neuroendocrine Subtype with Vulnerability to Aurora Kinase Inhibition

Cancer Cell 2017

(*contributed equally)

Johannes Brägelmann, Niklas Klümper, Anne Offermann, Anne von Mässenhausen, Diana Böhm, Mario Deng, Angela Queisser, Christine Sanders, Isabella Syring, Axel S. Merseburger, Wenzel Vogel, Elisabeth Sievers, Ignacija Vlasic, Jessica Carlsson, Ove Andrén, Peter Brossart, Stefan Duensing, Maria A Svensson, Zaki Shaikhibrahim, Jutta Kirfel, Sven Perner

Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer

Clinical Cancer Research 2017

2017